Transplantation of dedifferentiated fat cell-derived micromass pellets contributed to cartilage repair in the rat osteochondral defect model
نویسندگان
چکیده
منابع مشابه
Using Xenogenic (Calf Foetal) Osteochondral Transplantation for Articular Cartilage Defect in Rabbit Model
Background: The destruction of articular cartilage is the major cause of articular problems. The articular cartilage has little repair postertial due to lack of perichondrium and direct blood circulation. It is, therefore important to consider this phenomena in surgical treatments. One of the articular cartilage reconstructive surgeries is using Osteo-Chondral graft. The main purpose of this re...
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Background & Objective: Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSC transplantation for the repair of bone defects in the rat. Materials & Methods : Twenty-eight male adult rats were divided into 4 groups. Group 1 ( control group) received no treatment after the...
متن کاملStudy of Differentiation Potential of the Dedifferentiated Chondrocytes From Rat Articular Cartilage into Skeletal Cell Lineages
Purpose: Dedifferentiation of the chondrocyte from rat articular cartilage with multiple subcultures and study of the redifferentiation potential of the cells into bone, cartilage and fat cell lineages. Materials and Methods: In this experimental study, chondrocytes from rat articular cartilage were isolated and expanded through several successive subcultures during which the expression levels ...
متن کاملHuman Mesenchymal Stem Cell-derived Exosomes Promote Orderly Cartilage Regeneration in an Immunocompetent Rat Osteochondral Defect Model
Background : Although meniscal repair techniques have developed for several decades, meniscal repair of radial tears still remains challenging issue. For successful meniscal healing of radial tears, primary mechanical stability of meniscal repair is one of the essential requirements. All-inside vertical suture and Cross-suture techniques have been reported to provide superior stability compared...
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This study characterized peripheral blood mononuclear cells (PBMC) in terms of their potential in cartilage repair and investigated their ability to improve the healing in a pre-clinical large animal model. Human PBMCs were isolated with gradient centrifugation and adherent PBMC's were evaluated for their ability to differentiate into adipogenic, chondrogenic and osteogenic lineages and also fo...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Science
سال: 2018
ISSN: 0949-2658
DOI: 10.1016/j.jos.2018.03.001